University of Tokyo
Veterinary Internal Medicine
(Hematology & Oncology Team)
Japanese

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2019

 Asada, H., Tomiyasu, H., Goto-Koshino, Y., Ohno, K., Tsujimoto, H.
Effect of a two-base insertion mutation of the TP53 gene on expression of p53 protein in canine histiocytic sarcoma cells. Am J Vet Res 2019;80 680-688.
 

 Tomita, A., Mochizuki, H., Tsuboi, M., Ogura, I., Igarashi, H., Goto-Koshino, Y., Takahashi, M., Ohmi, A., Tomiyasu, H., Ohno, K., Nakagawa, T., Uchida, K., Nishimura, R., Tsujimoto, H.
Development of canine X-chromosome inactivation pattern analysis for the detection of cell clonality by incorporating the examination of the SLIT and NTRK-like family member 4 (SLITRK4) gene. Res Vet Sci 2019;125 170-175.
 

 Asada, H., Tomiyasu, H., Uchikai, T., Ishihara, G., Goto-Koshino, Y., Ohno, K., Tsujimoto, H.
Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell lines. PLoS One 2019;14 e0208567
 
 Kimura, H., Imura, Y.K., Tomiyasu, H., Mihara, T., Kaji, N., Ohno, K., Unno, T., Tanahashi, Y., Jan, T.R., Tsubone, H., Ozaki, H., Hori, M.
Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine. Sci. Rep. 2019;9 5887
 
 Son, N.V., Uchida, K., Thongtharb, A., Chambers, J.K., Kishimoto, T.E., Tomiyasu, H., Ohmi, A., Tsujimoto, H., Nakayama, H.
Establishment of cell line and in vivo mouse model of canine Langerhans cell histiocytosis. Vet. Comp. Oncol. 2019 in press
 
 Asada, H., Tomiaysu H., Okada, K., Chambers, J.K., Goto-Koshino, Y., Uchida, K.,  Kagawa, Y., Ohno, K., Tsujimoto, H.
Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma.  Res. Vet. Sci. 2019;124 57-60
 
  Asada, H., Ichii, O., Tomiaysu H., Uchida, K., Chambers, J.K., Goto-Koshino, Y., Ohno, K., Kon, Y., Tsujimoto, H.
The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma.  J. Vet. Med. Sci. 2019;81 353-356


 

2018

 Matsumoto, I., Nakashima, K., Goto-Koshino, Y., Chambers, J.K., Tsujimoto, H., Nakayama, H., Uchida, K.
Immunohistochemial Profiling of Canine Intestinal T-Cell Lymphomas Vet. Pathol. 2019;56 50-60.
 
 Tomiyasu, H., Doi, A., Chambers, J.K., Goto-Koshino, Y., Ohmi, A., Ohno, K., Tsujimoto, H.
Clinical and clinicopathological characteristics of acute lymphoblastic leukaemia in six cats. J. Small Anim. Pract. 2018;59 742-746.
 
 Motegi, T., Tomiyasu, H., Goto-Koshino, Y., Takahashi, M., Hiyoshi-Kanemoto, S., Fujino, Y., Ohno, K., Tsujimoto, H.
Prognostic value of CD44 variant isoform expression in dogs with multicentric high-grade B-cell lymphoma. Am. J. Vet. Res. 2018;79 961-969.
 
 Maeda, S.*, Tomiyasu, H.*, Tsuboi, M., Inoue, A., Ishihara, G., Uchikai, T., Chambers, J.K., Uchida, K., Yonezawa, T., Matsuki, N.  *Co-first authors
Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq. BMC Cancer 2018;18 472.
 
 Matsumoto, I., Uchida, K., Nakashima, K., Goto-Koshino, Y., Chambers, J.K., Tsujimoto, H., Nakayama, H.
Pathological features of intestinal T-cell lymphoma in Shiba dogs in Japan. Vet. Comp. Oncol. 2018;16 417-423.
 
 Sato, M., Mochizuki, H., Goto-Koshino, Y., Fujiwara-Igarashi, A., Takahashi, M., Ohno, K., Tsujimoto, H.
Prognostic significance of hypermethylation of death-associated protein kinase (DAPK) gene CpG island in dogs with high-grade B-cell lymphoma. Vet. Comp. Oncol. 2018;16:409-415.
 
 Matsumoto, I., Uchida, K., Nakashima, K., Hiyoshi, S., Chambers, J.K., Tsujimoto, H., Nakayama, H.
IgA Antibodies Against Gliadin and Tissue Transglutaminase in Dogs With Chronic Enteritis and Intestinal T-Cell Lymphoma. Vet. Pathol. 2018;55:98-107.


 

2017

 Suenaga, M., Tomiyasu, H., Watanabe, M., Ogawa, K., Motegi, T., Goto-Koshino, Y., Ohno, K., Sugano, S., Skorupski, K.A., Tsujimoto, H.
Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma. Vet. J. 2017;228 18-21.
 
 Asada, H., Tsuboi, M., Chambers, J.K., Uchida, K., Tomiyasu, H., Goto-Koshino, Y., Ohno, K., Tsujimoto, H.
A 2-base insertion in exon 5 is a common mutation of the TP53 gene in dogs with histiocytic sarcoma. J. Vet. Med. Sci. 2017;79(10) 1721-1726.
 
 Ohmi, A., Ohno, K., Uchida. K., Goto-Koshino Y., Tomiyasu, H., Kanemoto, H., Fukushima, K., Tsujimoto, H.
Significance of clonal rearrangements of lymphocyte antigen receptor genes on the prognosis of chronic enteropathy in 22 Shiba dogs. J. Vet. Med. Sci. 2017;79(9) 1578-1584.
 
 Yamazaki, H., Miura, N., Lai, Y.C., Takahashi, M., Goto-Koshino, Y., Yasuyuki, M., Nakaichi, M., Tsujimoto, H., Setoguchi, A., Endo, Y.
Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma in dogs. J. Vet. Med. Sci. 2017;79:1225-1229.
 
 Hara, K., Iio, A., Asahina, R., Takahashi, M., Mori, T., Nishida, H., Kamishina, H., Sakai, H., Kitoh, K., Mizuno, T., Tsujimoto, H., Maeda, S.
Characterization of a novel canine T-cell line established from a dog with cutaneous T-cell lymphoma. J. Dermatol. Sci. 2017;88:254-256.
 
 Yoshino, Y., Chambers, J.K., Nakamori, T., Goto-Koshino, Y., Nishigaki, K., Tsujimoto, H., Matsuki, N., Nakayama, H., Uchida, K.
Primary cerebellar lymphoma with Hodgkin lymphoma-like morphology in a cat. J. Vet. Diagn. Invest. 2017;29:707-710.
 
 Ohmura, S., Leipig, M., Schöpper, I., Hergt, F., Weber, K., Rütgen, B.C., Tsujimoto, H., Hermanns, W., Hirschberger, J.

Detection of monoclonality in intestinal lymphoma with polymerase chain reaction for antigen receptor gene rearrangement analysis to differentiate from enteritis in dogs. Vet. Comp. Oncol. 2017;15:194-207.

 

2016

 Scott, M.C.*, Tomiyasu, H.*, Garbe, J.R., Cornax, I., Amaya, C., O'Sullivan, M.G., Subramanian, S., Bryan, B.A., Modiano, J.F.　*Co-first authors
Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior. Dis. Model. Mech. 2016;9(12) 1435-1444.
 
 Weiskopf, K., Anderson, K.L., Ito, D., Schnorr, P.J., Tomiyasu, H., Ring, A.M., Bloink, K., Efe, J., Rue, S., Lowery, D., Barkal, A., Prohaska, S., McKenna, K.M., Cornax, I., O'Brien, T.D., O'Sullivan, M.G., Weissman, I.L., Modiano, J.F.
Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20. Cancer Immunol. Res. 2016;4(12) 1072-1087.
 
 Mochizuki, H., Fujiwara-Igarashi, A., Sato, M., Goto-Koshino, Y., Ohno, K., Tsujimoto, H.
Genetic and epigenetic aberrations of p16 in feline primary neoplastic diseases and tumor cell lines of lymphoid and non-lymphoid origins. Vet. J. 2017;219:27-33.
 
 Fujiwara-Igarashi, A., Tomiyasu, H., Igarashi, H., Yu, Y., Gogo-Koshino, Y., Ohno, K., Tsujimoto, H.
Regulation of p16 gene expression by histone H3 acetylation in canine lymphoid tumor cell lines. Jpn. J. Vet. Res. 2016;64:257-263.
 
 Kato, D., Takahashi, M., Harada, T., Tsuboi, M., Uchida, K., Fukushima, K., Kanemoto, H., Fujino, Y., Ohno, K., Nakayama, H., Tsujimoto, H.
Intranuclear inclusions in a dog with B-cell leukemia. Vet. Clin. Pathol. 2016;45:579-583.
 
 Roode, S.C., Rotroff, D., Richards, K.L., Moore, P., Motsinger-Reif, A., Okamura, Y., Mizuno, T., Tsujimoto, H., Suter, S.E., Breen, M.
Comprehensive genomic characterization of five canine lymphoid tumor cell lines. BMC Vet. Res. 2016;12:207.87.
 
 Sato, M., Yamazaki, J., Goto-Koshino, Y., Setoguchi, A., Takahashi, M., Baba, K., Fujino, Y., Ohno, K., Tsujimoto, H.
Minimal residual disease in canine lymphoma: An objective marker to assess tumour cell burden in remission. Vet. J. 2016;215:38-42.
 
 Mizutani, N., Goto-Koshino, Y., Takahashi, M., Uchida, K., Tsujimoto, H.
Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma. J. Vet. Med. Sci. 2016;78:1237-44.
 
 Mizutani, N., Goto-Koshino, Y., Tsuboi, M., Kagawa, Y., Ohno, K., Uchida, K., Tsujimoto, H.
Evaluation of CD25-positive cells in relation to the subtypes and prognoses in various lymphoid tumours in dogs. Vet. Immunol. Immunopathol. 2016;173:39-43.
 

 Hiyoshi-Kanemoto, S., Goto-Koshino, Y., Fukushima, K., Takahashi, M., Kanemoto, H., Uchida, K., Fujino, Y., Ohno, K., Tsujimoto, H.
Detection of circulating tumor cells using GeneScan analysis for antigen receptor gene rearrangements in canine lymphoma patients. J. Vet. Med. Sci. 2016;78:877-81.

 
 Koshino, A., Goto-Koshino, Y., Setoguchi, A., Ohno, K., Tsujimoto, H.

Mutation of p53 Gene and Its Correlation with the Clinical Outcome in Dogs with Lymphoma. J. Vet. Intern. Med. 2016;30:223-9.

 
 Maeda, S., Ohno, K., Fujiwara-Igarashi, A., Uchida, K., Tsujimoto, H.

Changes in Foxp3-Positive Regulatory T Cell Number in the Intestine of Dogs With Idiopathic Inflammatory Bowel Disease and Intestinal Lymphoma. Vet. Pathol. 2016;53:102-12.

 

2015

 Scott, M.C., Sarver, A.L., Tomiyasu, H., Cornax, I, VamEtten, J., Varshney, J., O’Sullivan, M.G., Subramanian, S. and Modiano, J.F.
Aberrant RB-E2F Transcriptional Regulation Defines Molecular Phenotypes of Osteosarcoma. J. Biol. Chem. 2015;290(47) 28070-28083.
 
 Tomiyasu, H. and Tsujimoto H. Comparative Aspects of Molecular Mechanisms of Drug Resistance through ABC Transporters and Other Related Molecules in Canine Lymphoma. Vet. Sci. 2015;2(3) 185-205.
 
 Asada, H., Tomiyasu, H., Goto-Koshino, Y., Fujino, Y., Ohno K. and Tsujimoto, H. Evaluation of the drug sensitivity and expression of 16 drug resistance-related genes in canine histiocytic sarcoma cell lies. J. Vet. Med. Sci. 2015;77(6) 677-684.
 
 Fujiwara-Igarashi, A., Igarashi, H., Mizutani, N., Goto-Koshino, Y., Takahashi, M., Ohno, K., Tsujimoto, H.

Expression profile of circulating serum microRNAs in dogs with lymphoma. Vet. J. 2015;205:317-21.

 
 Goto-Koshino, Y., Mochizuki, H., Sato, M., Nakashima, K., Hiyoshi, S., Fujiwara-Igarashi, A., Maeda, S., Nakamura, K., Uchida, K., Fujino, Y., Ohno, K., Tsujimoto, H.

Construction of a multicolor GeneScan analytical system to detect clonal rearrangements of immunoglobulin and T cell receptor genes in canine lymphoid tumors. Vet. Immunol. Immunopathol. 2015;165:81-7.